Cutaneous Miscellaneous - Episode 20 - Board Booster

Introducing Cutaneous Miscellaneous Boards Booster. Each episode will feature high-yield board review questions pertaining to the board review topic discussed. Questions and answer explanations are written and edited by current dermatology residents/fellows and are sourced from key resources such as Bolognia Dermatology, Andrews’ Dermatology and Alikhan’s Review of Dermatology.

Question Title

* A biopsied lesion shows infiltrative small vessels with bland endothelium, plasma cells, RBC extravasation, and hemosiderin deposition. Which of the following has the highest diagnostic sensitivity and specificity?

a. CK5/6

b. S100

c. LANA-1

d. CD31+

Question Title

* Among the following lesions with pagetoid scatter, which one is CK/CEA positive and S100/LCA negative?

a. Bowen’s

b. Melanoma

c. Sebaceous carcinoma

d. Paget’s

Question Title

* Which of the following melanoma subtypes has all of the following: Melan-A and HMB-45 negative, S100+, and SOX10+?

a. Desmoplastic melanoma

b. Melanoma in situ

c. Spitzoid melanoma

d. Uveal melanoma

Question Title

* A patient who has renal cell carcinoma is found to have many tender erythematous papules on his abdomen. Which of the following stains is most likely to be positive?

a. S100

b. TTF-1

c. CEA

d. Desmin

Question Title

* A lesion on the scalp of a 67-year-old male is biopsied. Histology shows an infiltrative dermal mass composed of sheets of uniform basaloid cells, finely speckled chromatin without prominent nucleoli, and numerous mitoses. Staining is positive for neurofilaments and neuron-specific enolase. Which of the following stains will also be positive?

a. TTF-1

b. CK7

c. CD56

d. S100

e. CEA