Cutaneous Miscellaneous - Episode 25 - Board Booster

Introducing Cutaneous Miscellaneous Boards Booster. Each episode will feature high-yield board review questions pertaining to the board review topic discussed. Questions and answer explanations are written and edited by current dermatology residents/fellows and are sourced from key resources such as Bolognia Dermatology, Andrews’ Dermatology and Alikhan’s Review of Dermatology.

Question Title

1. Epidermolysis bullosa simplex is caused by mutation(s) in which of the following gene(s)? (Required.)

Collagen 7

Keratin 5 and 14

Keratin 7 and 11

Laminin 332

Question Title

A 17-year-old boy who has had blistering since birth has now started to develop muscle weakness and scarring hair loss. A mutation in which of the following is likely responsible for his condition? (Required.)

Collagen 7

Integrin α6β4

Keratin 5

Keratin 14

Plectin

Question Title

Electron microscopy is the gold standard for the diagnosis of EB through ultrastructural evaluation of the cleavage plane of a fresh induced blister. What is the preferred fixative for electron microscopy? (Required.)

Saline

Glutaraldehyde

Anaerobic tissue transport medium (ATTM)

HypoThermosol

Eagle’s media

Question Title

Junctional epidermolysis bullosa is caused by fragility and separation of the skin causing blisters at what layer/component? (Required.)

Stratum spinosum

Stratum basale

Lamina lucida

Hemidesmosomes

Desmosome

Question Title

A young patient presents with a history of generalized blisters that cause significant scarring and milia after healing. This patient has a high risk of developing what condition at an earlier age that usual? (Required.)

Squamous cell carcinoma

Respiratory distress

Cardiomegaly

Cataracts

Renal failure

Cutaneous Miscellaneous - Episode 25 - Board Booster

Question Title

* 1. Epidermolysis bullosa simplex is caused by mutation(s) in which of the following gene(s)? (Required.)

Question Title

* A 17-year-old boy who has had blistering since birth has now started to develop muscle weakness and scarring hair loss. A mutation in which of the following is likely responsible for his condition? (Required.)

Question Title

* Electron microscopy is the gold standard for the diagnosis of EB through ultrastructural evaluation of the cleavage plane of a fresh induced blister. What is the preferred fixative for electron microscopy? (Required.)

Question Title

* Junctional epidermolysis bullosa is caused by fragility and separation of the skin causing blisters at what layer/component? (Required.)

Question Title

* A young patient presents with a history of generalized blisters that cause significant scarring and milia after healing. This patient has a high risk of developing what condition at an earlier age that usual? (Required.)

1. Epidermolysis bullosa simplex is caused by mutation(s) in which of the following gene(s)? (Required.)

A 17-year-old boy who has had blistering since birth has now started to develop muscle weakness and scarring hair loss. A mutation in which of the following is likely responsible for his condition? (Required.)

Electron microscopy is the gold standard for the diagnosis of EB through ultrastructural evaluation of the cleavage plane of a fresh induced blister. What is the preferred fixative for electron microscopy? (Required.)

Junctional epidermolysis bullosa is caused by fragility and separation of the skin causing blisters at what layer/component? (Required.)

A young patient presents with a history of generalized blisters that cause significant scarring and milia after healing. This patient has a high risk of developing what condition at an earlier age that usual? (Required.)